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In addition, gut microbiota and gut microbiome-derived metabolite, indole-3-acetic acid, were also reported to contribute to the efficacy of SFN in improving HFD-induced hepatic steatosis along with Aryl hydrocarbon receptor (AHR)/SREBP1c pathway-mediated lipid metabolism (Xu et al., 2021)

Aquaporin-8 (AQP8) facilitates H 2 O 2 diffusion in GI (121)