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Consistently, increased levels of GLP-1 and insulin could be observed in MMI + T3-5d mice compared to MMI mice even without oral glucose load (Fig

While GLP1 receptor agonists have long been recognized for their glucose-lowering and weight-loss effects, they now offer potential for improving liver outcomes, especially in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) or its more advanced form, metabolic dysfunction-associated steatohepatitis (MASH)

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In the current study, we report DPP4 was elevated 4-fold in Pemt / mice, which have both hepatomegaly and nonalcoholic steatohepatitis (54), demonstrating that in addition to obesity, liver-specific insults can induce the release of DPP4