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In general, all roads lead to Rome and any of these portals can be used to get the medication into the knee joint where it mixes with the synovial fluid and circulates around the knee (thus you dont necessarily have to have an injection on the inside of the knee just because your pain is mostly on the inside)

However, the concentration of L-NAME and the time of exposure may need some adaptations depending on the research interest and the type of cells in use

Liquid-exfoliated mesostructured collagen from the bovine achilles tendon as building blocks of collagen membranes

Environ Sci Pollut Res 27(9):89538964

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