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Effect of linagliptin vs glimepiride on major adverse cardiovascular outcomes in patients with type 2 diabetes: the CAROLINA Randomized Clinical Trial

Nutrient deficiencies develop when semaglutide reduces food intake without intentional supplementation

Vagal neurons are a major site for peripheral GLP-1 action, mediating gut-brain communication for the regulation of feeding, gastric emptying, and glucose metabolism [72]

High-bioavailability drugs with wide therapeutic windows Drugs like metformin, statins (most are highly absorbed across a wide pH range), and most SSRIs have wide enough therapeutic windows that a modest delay in Tmax is unlikely to produce clinical consequences

However, the association between DPP-4 inhibitor use and suicidal behaviors mirrored that of GLP-1 RA, further supporting the accuracy of the findings