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That single distinction, the receptor each one targets, explains almost everything else about how these three peptides behave in published studies
Kisspeptin: controls GnRH neurons and puberty onset
Conditions with strong preclinical evidence such as tendon injuries, gastric ulcers, and inflammatory bowel disease represent logical initial targets for clinical investigation
The most important are the 78 kDa glucose regulatory protein (GRP78) and protein disulfide isomerase (PDI)
In 2024, both were removed from Category 2 after the nominations were withdrawn, not because they were judged safe
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