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Traditional obesity intervention strategies (e.g., dietary control, exercise, conventional weightloss drugs) are often limited by slow onset, obvious side effects, and high rebound rates, and can hardly fundamentally reverse the abnormal metabolic phenotype of adipose tissue
Furthermore, the weightloss effect of the product was shown to be sustainable, with no significant body weight rebound in the short term after drug withdrawal, a feature superior to traditional antiobesity medications
In obesity, abnormal adipose metabolism transports large amounts of free fatty acids to the liver, increasing hepatic fat synthesis, decreasing fat breakdown, and ultimately causing hepatic steatosis
Therefore, exploring the combined application of NNMTi with other interventions has become a research hotspot in recent years
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