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LPS stimulation of THP-1 cells from RA patients results in enhanced histone H3 and H4 acetylation at the CCL2 promoter (77)
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The lungs maintain high glutathione concentrations in the epithelial lining fluid, where it protects against oxidative damage from inhaled pollutants and supports local immune function
In addition, there are a group of NOX (NADPH oxidases) enzymes located on the cell membrane of polymorphonuclear cells, macrophages and endothelial cells, that facilitate the conversion of oxygen into superoxide on biological membranes using NADPH as an electron donor with ROS released as secondary products (Figure 1)
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