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Studies have used continuous daily dosing for up to 2 years without loss of efficacy
To overcome these limitations, herein, the tumor-selective transport of a physiological stable ruthenium-based catalyst for the oxidation of GSH into GSSG as a nanoreactor is proposed
Reagents The following antibodies and their corresponding Research Resource Identifiers (RRIDs) were used in this study: SLC25A39 (RRID: AB_2878095, AB_2605624), SLC25A40 (RRID: AB_1310678), AFG3L2 (RRID: AB_2637746, AB_1209606), HSP60 (RRID: AB_881444), -actin (RRID: AB_10950489), GAPDH (RRID: AB_307272), cleaved caspase-3 (RRID: AB_302962), cleaved caspase-9 (RRID: AB_2889070), cleaved PARP (RRID: AB_777102), HEY1 (RRID: AB_2576326), pro-caspase-3 (RRID: AB_2069711), pro-caspase-9 (RRID: AB_2809709), HES1 (RRID: AB_2546278), and NOTCH1 (RRID: AB_467579)
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