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Previous studies have shown that AP2 enhances somatic gene repression and germline program activation during PGC specification
Most clinical trials have looked at weight loss and blood sugar control
It is acknowledged that activation of STAT3 which is crucial to M2 phenotype transformation, while STAT1 activity which is a key determinant for the M1 subtype
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The destruction of the mitochondrial electron transport chain (ETC) leads to an increase in ROS production, which triggers matrix metalloproteinases (MMP) induction, ultimately disrupting tight junctions and increasing BBB permeability
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