(2) The first isolation of the peptide was carried out in 1920, followed by its structure discovery in the 1950s
For example, in pea plants susceptible to Plum pox virus (PPV), systemic PPV infection produced chlorotic and necrotic lesions, a pronounced oxidative stress indicated by increased protein oxidation, lipid peroxidation, elevated H 2 O 2 levels and electrolyte leakage in infected leaves (Daz-Vivancos et al., Rice black-streaked dwarf virus (RBSDV) displayed an induction of GST23 and the corresponding transcripts, concomitant with oxidative stress (Xu et al., 2013)

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This finding strongly supports the necessity of RAMP1 and RAMP3 for mediating cagrilintide-induced weight loss through AMY1R and AMY3R signaling [2]
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