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"This next step in our partnership with the MHRA will generate data and evidence for safer and more effective treatment through more personalised approaches to prescription, supporting a shift towards an increasingly prevention-focused healthcare system."
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The present update preserves the hierarchy for weight-loss efficacy while adding direct comparative evidence from SURMOUNT-5 and substantially more complication-specific randomized data (Aronne 2025)
However, you should keep in mind that correlation doesnt mean causation
Endocrine disorders such as MEN 2 (Multiple Endocrine Neoplasia type 2 syndrome) Due to the potential risk for thyroid cancer, you should not use tirzepatide if you have a personal or family history of MTC or MEN 2 syndrome
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