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The primary mechanism of action involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent mannermeaning it only triggers insulin release when blood sugar levels are elevated

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Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig