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Others experience symptom changes within days to weeks

Moreover, THBS1 can mitigate the menstruation-driven inflammatory response by binding to cell-surface receptors (such as a4b1 integrin) of inflammatory cells, thereby restoring the overall immune homeostasis when proceeding to the next stages of the menstrual cycle [18]

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These effects are typically manageable and often subside with time

However, like most other medical treatments their efficacy would depend on the patient and extent of these hyperpigmentations or scarification processes