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Glycemic effects remain relevant, particularly in patients with prediabetes or insulin resistance, but they are no longer the defining measure of success

Patients with specific FTO or GLP1R variants may experience greater initial reflux or require more gradual dose escalation

However, this antioxidant effect was significantly reversed by MK2 inhibitor treatment, which increased ROS levels by approximately 40%50% relative to the H 2 O 2 + MAPKAPK2 group (Figure 4C)