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Each step up delivered approximately 3 additional percentage points of weight loss, suggesting the compound was still climbing toward its ceiling at the highest dose

[6] The investigators concluded that the lipolytic actions were not explained by direct beta-3-receptor activation, although increased receptor expression could contribute to enhanced lipolytic sensitivity after longer exposure

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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept