health benefits of glp-1 agonists Frontiers Long-term Success of GLP-1s Hinges

It fills a gap that hormone therapy alone can't always address

Connection between weight loss and better sleep Obesity represents the primary modifiable risk factor for obstructive sleep apnea (OSA) 34

For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]

Quinone reductase 2 as a promising target of melatonin therapeutic actions

Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, et al