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Observational and review-level evidence indicates that patients receiving GLP-1RAs may exhibit micronutrient insufficiencies and lean mass reduction, particularly in vulnerable populations or during prolonged therapy [94, 101]
It has been noted that there is a lack of placebo-controlled randomized trials with liver histology outcomes
Food And Drug Administration
The schedule mirrors the clinical-trial protocols that drove substantial weight loss around 20% of body weight over 72 weeks on the 15 mg dose [2] while holding gastrointestinal effects down through gradual escalation [1] [4]
How is ongoing research contributing to the understanding of semaglutide safety
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