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Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form
In vitro, IL-10 treatment directly stimulated -endorphin expression in primary microglia [63]
The side effect profile appears similar to existing GLP-1 medications, with gastrointestinal symptoms like nausea, vomiting, diarrhea, and constipation being most common
Together, these effects reduce appetite and make it easier to eat less without constant hunger
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