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The 72-hour threshold is not an official manufacturer guideline it's a practical working limit based on how quickly bacterial growth can become concerning at typical room temperatures (2025C) even in the presence of benzyl alcohol
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For patients with severe cases of anemia or B12 vitamin deficiencies, a form of vitamin B12 called Hydroxocobalamin is sometimes used and does require a prescription
A vial stored at a rock-steady 4 degrees Celsius will outlast the same formulation subjected to temperature cycling between 2 and 8 degrees multiple times per day
Vitamin B12: Fact Sheet for Consumers [Internet]
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