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10.1097/00006534-200005000-00019 81 NumataY.TeruiT.OkuyamaR.HirasawaN.SugiuraY.MiyoshiI.et al (2006)
found that in AD and tau protein deposition models, it can reduce the formation of neurofibrillary tangles (NFT) in cerebral tissue and decrease amounts of phosphorylated tau protein, thereby exerting protective effects
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Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19
FDA's Official Reasons: Lack of Clinical Trials: The FDA emphasizes the need for extensive, controlled clinical trials, which are currently lacking
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