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The levels of PTBP1 crotonylation are elevated in CRC tissues, primarily occurring at lysine 266, with KAT2B identified as the crotonyl transferase at this site
See our tirzepatide research guide for comparison context
PT-141 was originally discovered as a side effect during research on melanotan II, a synthetic tanning peptide
Transl Res 161:7384 Ribas GS, Vargas CR, Wajner M (2014) l-Carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders
Reductions of this magnitude are rare in addiction medicine and whats remarkable is that the finding came from drugs initially designed for diabetes, later repurposed for obesity and never intended to treat addiction
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