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doi: 10.1038/s41418-023-01153-w 13 LiuZWangSWangWLvRSunC

Efficacy and Limitations Despite the claims, many health experts express skepticism regarding the effectiveness of these GLP-1 supplements for substantial weight loss

In cohorts of patients with type 2 diabetes, several studies have reported elevated levels of long-chain and specific short-chain acylcarnitines during the microalbuminuria stage (UACR 30300 mg/g), indicating that early metabolic changes in the kidneys may precede mitochondrial dysfunction and impaired fatty acid oxidation [17, 144,145,146]

It allows for a graded approach by increasing weekly doses in 2mg increments, minimizing the risk of gastrointestinal side effects