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The pharmacokinetic profile supports once-weekly dosing, with a half-life of approximately five days

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doi: 10.1016/j.pbi.2025.102705 26 ChenSGlawischnigEJrgensenKNaurPJrgensenBOlsenCEet al

Another consideration for GLP-1/GIP/GCG agonists is their potential negative impact on lean mass [32]

Around 85% of people experience plateaus due to metabolic changes, dosage needs, muscle loss, hidden calories, reduced activity, hormonal shifts, or your bodys natural weight "set point." Heres why it happens and how to overcome it: Metabolism slows down as you lose weight