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Key Points The central and peripheral melanocortin system has multifaceted roles in the control of body-weight homeostasis, sexual behaviour, and autonomic and cardiovascular functions, and so targeting this pathway has potential for the treatment of multiple clinical disorders

It's actively disrupting lipid metabolism in a way that requires medical management, often through dietary changesspecifically, reducing fat and sugar intake

An initial 3D model was built in Relion with both C1 and C2 symmetry and used for subsequent 3D classifications and refinements

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Epidural Steroid Injections Epidural injections deliver corticosteroids directly to the inflamed nerve root