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Miscellaneous: Other causes of constipation get lumped into the miscellaneous category and include, celiac disease, inflammatory bowel disease (IBD), cystic fibrosis, and more
Choosing a medication depends on medical history, current conditions, and treatment goals
Influence of acute tryptophan depletion on gastric sensorimotor function in humans
A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)
They concluded that the net price of Zepbound would have to come down by 31% and the net price of Wegovy would have to come down by 82% for these drugs to be cost-effective at $100,000 per QALY
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