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Note: While TB-500 is often discussed as thymus-derived, it is a synthetic fragment not naturally produced in the thymus

Signs and symptoms of vitamin B12 deficiency can include fatigue, pale skin, headaches, shortness of breath, fast heartbeat, gastrointestinal issues, mouth inflammation, paresthesias (abnormal sensations), decreased cognitive ability, depression, muscle weakness, imbalance and incoordination, vision problems, and erectile dysfunction

The transcobalamin-bound fraction, known as holotranscobalamin or active B12, accounts for 6%-20% of bound vitamin B12