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Diabetes Obes Metab 17(Suppl 1):99105

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In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121

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Research has characterised MT-IIs transient blood pressure and heart rate changes , documenting central autonomic melanocortin receptor-mediated cardiovascular effects following MT-II administration through hypothalamic MC4R activation of sympathoadrenal outflow