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There were no significant between-group differences in any baseline variable
This modification restricts the nuclear translocation of Nrf2, thereby suppressing the expression of GPX4
Ferroptosis is regulated by the cystine/glutamate antiporter system (xCT), which imports cystine into cells in exchange for glutamate ( KYN has been shown to inhibit ferroptosis by upregulating the expression of xCT, thereby enhancing cystine import and glutathione synthesis ( Figure 1B )
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