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Chien-Shiung Wu in a laboratory at Columbia University, in a photo dating back to 1958

Weight loss improves knee OA, with studies showing a 2% improvement in the WOMAC pain, function, and stiffness scores for every 1% reduction in body weight

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[1] When combined, the cumulative effect on heart rate and blood pressure may be clinically significant, particularly in patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias

If you weigh under 70 kg (154 lbs), 3 grams may be sufficient