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Animal experiment At six weeks of age, fifty male and female C57BL/6 mice were kept in controlled environments with a temperature of 25 C 2 C, a relative humidity of 50 5%, and a light and dark cycle of 12 h

The "retinol uglies" (peeling, redness, purging, and stinging that typically last 2 to 6 weeks but can extend beyond a month) are not a side effect

These combine to minimize irritation while amping up antioxidant protection and ingredient stability. Thats how you get to a 25% Vitamin C concentration without risk of irritation

Biochem Biophys Res Commun 289 : 212219, 2001