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These observations imply that ROS function not simply as indicators of oxidative stress during treatment, but also may converge on specific signaling nodessuch as DNA damage response pathways, kinase networks, and mitochondrial remodelingto stabilize drug-resistant cellular states ( Figure 3 )
This reaction is catalysed by a family of aminotransferases to produce alanine [46] , aspartate [47] , serine [48] , proline [49] and ornithine [50]
BMJ Open
doi: 10.1111/bph.12608 110 LiuJGaoDDingQZhangBZhuWShiY
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