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While individuals who are not overweight can suffer from a chronic disease, obesity is a significant risk factor for many chronic illnesses, from heart disease and diabetes to cancer and Alzheimers
Zafardoust S, Kazemnejad S, Darzi M, Fathi-Kazerooni M, Rastegari H, Mohammadzadeh A
Three hundred patients with HFrEF hospitalized for acute heart failure within 14 days and taking diuretics equivalent to at least 40 mg furosemide were randomized to receive 1.8 mg per day of liraglutide or placebo in FIGHT [27]
However, both reviews note that the findings should be interpreted with a grain of salt due to small sample sizes.21 22 In contrast to those findings, a placebo-controlled trial from early 2025 with over 1,000 subjects found no clear evidence that TA-1 decreased 28-day all-cause mortality in adults with sepsis.23 This ultimately means that more well-designed large-scale trials are needed to determine whether or not TA-1 can actually reduce mortality from sepsis
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