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They respond best to coordinated strategies that address multiple mechanisms

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When the majority of that literature originates from a single research group, uses the same animal model, and has not been independently replicated, the effective evidence base is narrower than the publication count implies

A key practical limitation is the difficulty of maintaining long-term adherence to ketogenic interventions, which may reduce their feasibility and sustainability in dermatological practice

It is normal for the solution to darken slightly over time under refrigeration, particularly due to the riboflavin content