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discontinue if weight loss is less than 5% Regular weight measurements and BMI calculations Monitoring for adverse effects, particularly gastrointestinal symptoms Blood pressure and cardiovascular risk factor assessment Periodic blood tests to monitor metabolic parameters For patients with diabetes who are taking insulin or sulfonylureas, doses of these medications may need to be reduced when starting GLP-1 receptor agonists to prevent hypoglycaemia

Rapid subcutaneous desensitization for the management of local and systemic hypersensitivity reactions to etanercept and adalimumab in 12 patients

Future Research Directions Given the limited but promising data, researchers are interested in launching more trials to test semaglutide specifically for RA

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