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The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice ( c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)

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Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

Wen, Q., Liu, J., Kang, R., Zhou, B

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