safety of retatrutide Full article: Efficacy and triple hormone receptor agonist for the management of obesity: a systematic review and meta-analysis What is retatrutide, its mechanism

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In addition to its critical role in the survival of sensory neurons and neurite outgrowth, NGF signalling is also involved in nociception by activating nociceptive neurons, which express high-affinity NGF receptors [27]

Exclusion criteria included end-stage illness, dialysis, renal transplantation, severe pancreatic disorders, bowel obstruction or major surgery of the intestines before cohort entry, the diagnosis of drug misuse within one year of cohort entry, and the diagnosis of diseases (e.g., inflammatory bowel disease, neoplasms, or hernias) that could cause constipation or intestinal obstruction within 90 days of cohort entry

For the measurement of GIP, a Rat/Mouse GIP (total) ELISA kit (EZRMGIP-55K, Merck/millipore) was used