If successful in real-world deployment, auditable concept-grounded foundation models could make clinical AI tools more reliable, easier to validate, and faster to integrate into decision support systems
When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells
Adverse events were reported by 79% of participants receiving semaglutide and 82% receiving placebo
Ozempic (for type 2 diabetes) is available in three pre-filled pen strengths in the US: 2 mg/1.5 mL pen (1.34 mg per mL) - delivers 0.25 mg or 0.5 mg doses 4 mg/3 mL pen (1.34 mg per mL) - delivers 1 mg doses 8 mg/3 mL pen (2.67 mg per mL) - delivers 2 mg doses Wegovy (for weight management) comes in single-dose pens with concentrations of 0.25 mg/0.5 mL (0.5 mg/mL), 0.5 mg/0.5 mL (1 mg/mL), 1 mg/0.5 mL (2 mg/mL), 1.7 mg/0.75 mL (2.27 mg/mL), and 2.4 mg/0.75 mL (3.2 mg/mL)
In such instances, the presence of structural pancreatic disease (Tier 1) in combination with diabetes should prompt a diagnosis of PDM, and there should be continued functional reassessment over time