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( 1S,3R )-RSL3 forms covalent bonds with GPX4, which is inactivated via alkylating the selenocysteine and leads to toxic lipid peroxides buildup, and inevitable cell death (Yang et al., 2014
Oral iron supplementation: potential implications for the gut microbiome and metabolome
Chairs Summation Prof Thci concluded by discussing the future research needed regarding the broad effects of fumarates in psoriasis and how both this class of drugs and IL-23 inhibitors should be considered for use in long-term therapy.
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R.MarquesE.TurnerK.et al (2025)
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