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Drugs Drug Candidates
The three mouse models were SAMP-1 female mice with accelerated aging, wild rats, SAMR-1, and SHR (both female mice)
Notably, the observed variability in efficacy between agents, particularly in the early phases of treatment, emphasizes the importance of individualized therapeutic strategies, tailored to specific clinical goals, baseline metabolic profiles, and patient preferences
In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise
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