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Thyroid function can downregulate
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These effects seem to be particularly mediated by an anti-atherogenic effect of GLP-1Ra as confirmed by animal models of hyperglycemia where liraglutide-based therapy reduced lipid deposition and plaque volume on the aortic surface according to glucose levels amelioration [152]
When it comes to shedding those extra pounds, two heavyweight contenders have taken the spotlight Semaglutide and Tirzepatide (Mounjaro)
Nat Neurosci 24(7):913929 Dong Y et al (2021) Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo
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