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The second is tolerability, since gastrointestinal effects and discontinuation rates differ across candidates and are becoming a real point of differentiation, as set out in the full side-effect profile of the GLP-1 class
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Regular physical activity helps preserve lean muscle mass during weight reduction, which is particularly important since approximately 25% to 40% of weight lost with GLP-1 agonists alone may come from lean tissue rather than fat, according to body composition studies
PLoS One 9 , e98972 (2014)
While it has shown promising results, it is important to consider the potential side effects, cost, and the need for further research to determine its long-term safety and efficacy
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