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doi: 10.3389/fendo.2021.806819 Received 01 November 2021 Accepted 17 November 2021 Published 14 December 2021 Volume 12 - 2021 Edited by Fang Zhongze, Tianjin Medical University, China Reviewed by Lihong Ye, Nankai University, China

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The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

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