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Alongside these benefits of GLP-1RAs, however, is an increased propensity for GI adverse events, notably nausea, when compared with insulin

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In the FLOW trial, semaglutide reduced the risk of kidney diseases, including kidney failure or death, by 24% compared to placebo

Niacinamide is has been shown to reduce pigmentation by inhibiting melanosome transfer using a skin-co-culture model (126), whilst soymilk and soybean extracts have been previously suggested to inhibit protease-activated receptor 2 activation in the skin, which may enhance pigment transfer that results in skin whitening (127,128)

[PMID: 9299530] PubMed record related to this compound for laboratory literature review