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XRCC4 consists of 336 amino acids and bears a globular head at the N-terminus and a coiled-coil tail at the C-terminus (C-ter) that mediates dimerization and interaction with Lig4
These results suggest that epigenetic inactivation of GSTP1 plays an important role in the development of HCC and exposure to environmental carcinogens may be related to altered methylation of genes involved in hepatocarcinogenesis (Zhang et al., 2012)
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doi: 10.1007/s10787-022-01057-0 216 El-MiligyMMMAl-KubeisiAKBekhitMGEl-ZemitySRNassraRAHazzaaAA
The GSH concentration was measured over 90 min under 37 C anaerobic culture
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