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Rosenfield RL, Deplewski D, Kentsis A, Ciletti N

6.2 Irisin and the endocrinology of exercise Irisin, a peptide cleaved from the transmembrane protein FNDC5 and released from skeletal muscle during exercise, represents a parallel and more controversial example of muscle-derived endocrine signaling

It is found naturally in all the cells of the body, certain fruits and vegetables, fungi and some bacteria

Z-D-Phe-Arg(HCl)-Trp-Lys( Boc)-NH 2 ( 7 ) 2 A solution of HCl in dioxane (17%, 50.3 mL as calculated from the acid-base titration of product 6 obtained from the previous step) was added dropwise to a stirred solution of protected dipeptide 6 (134.5 g, 295.3 mmol) in DMF (800 mL) at 7 C

Nat Rev Cancer (2004) 4:57991