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Age further increases TTR amyloid risk due to declining proteostasis and reduced chaperone capacity, helping explain the strong association between ATTR and advanced age

GH Pulse Kinetics Pharmacokinetic modelling in healthy male subjects showed that plasma Ipamorelin levels persisted longer than plasma GH levels and continued to drive smaller secondary GH pulses, with peak GH concentration occurring at approximately 0.67 hours post-administration and declining to low levels by 6 hours

They have come into the limelight after a large double-blinded study published in NEJM, showed an average 14.9% decrease in weight in obese patients given semaglutide on top of lifestyle modifications, compared to 2.4% in the control arm (see research summary at end)

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Pratley will detail FLOW design and baseline characteristics