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3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)

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Brand protection strategies should be designed in parallel with formulary defense strategies: the patent term extension or new indication approval that extends exclusivity should also extend the period during which the manufacturer can negotiate formulary necessity rather than formulary competition