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Ethics declarations Competing interests M.M.V., S.C.L., L.A., R.K., S.S., Y.C., B.W., J.R.F., T.H., V.A.T., M.A., L.S., Y.Z., V.K., R.J., R.K.O., J.R.P., N.H

Copper binding occurs through histidine imidazole nitrogen and N-terminal amino group, forming stable 1:1 complex

Seek immediate medical attention for signs of severe allergic reaction including difficulty breathing, facial swelling, or widespread urticaria

In FM, altered methylation patterns have been observed, leading to changes in gene expression that contribute to the development and maintenance of chronic pain [68]

Patient assistance programs, manufacturer coupons, and discount pharmacy networks (GoodRx, RxSaver, SingleCare) may reduce branded medication costs