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Turnbull PC, Dehghani AC, Theriau CF, Connor MK, Perry CGR

GLP-1 receptor agonists (e.g., semaglutide, dulaglutide, liraglutide) work by mimicking natural GLP-1 hormone to stimulate insulin secretion, suppress glucagon, slow gastric emptying, and promote satiety

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Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis