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In the ELIXA [66], EXSCEL [68], and PIONEER 6 [67,71] studies, treatments of exenatide twice-daily, exenatide once-weekly, and oral semaglutide groups were non-inferior to placebo in terms of CV disease safety, respectively
Similarly, serum and BALF IgE content have consistently increased in experimental animal models of allergic asthma produced by OVA [42, 43]
Research shows it enhances fibroblast migration to injury sites through the FAK-paxillin pathway, improves collagen fiber organization and cross-linking, promotes angiogenesis to improve nutrient delivery, and reduces inflammatory mediators while preserving beneficial healing signals
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142,143 In addition, chronic inflammation promotes Nrf2-induced TGF- expression, which also has a main role in the progression of pulmonary fibrosis
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